Process Development for client’s plant scale-up

A new client approached us with a molecule of interest. They supplied us with the target and a number of patents and research papers providing a 2 step synthesis. The objective was to develop a route in good yield and purity that was within the capabilities for their plant to produce in bulk.

Our proposal was accepted.

Prosynth already had experience of the first step and this was modified to use different solvent and hence stoichiometric amounts of benzene.

In the second step one reagent was replaced for another to allow for easier purification.

The modifications at both steps of the synthesis were successful and in the second step to the point where this needed no further purification.

The customer received 1.5kg as a sample plus a report. In accordance with our business model the customer receives all information gained, Prosynth retains no IP.

Author: Howard D. Craven, May 2018