Reaction Types

Equipment / Facilities

  • In-house scales of 100g – 100kg, usually operating in 20-50L glassware
  • Five 60L, 4 bar Stainless Steel reactors
  • Nine Rotary Evaporators (four 20L)
  • Temperatures from minus 150 (liquid nitrogen) to 200 degrees
  • Pressure to 4 bar (2 Parr ™ shakers)
  • High Vacuum Fraction Distillation with a range of high resolution columns
  • Chromatographic Purification – Jones, Biotage™ and large packed columns
  • Short Path Wiped Film Evaporator

Chemistry Highlights

All the classics and many more…

  • Organometallics – extensive use of n-Butyl and sec-Butyl lithium & Grignard chemistry
  • Precious metal catalysis – a wide range of coupling reactions (and production of substrates such as boronates)
  • Friedel-Crafts acylation
  • Reduction chemistry – using hydride reagents, boranes, dissolving metals and hydrogenation
  • Chiral intermediates – by chiral pool synthesis, by chiral induction and by classical resolution
  • Heterocycle ring building